Diazepam is extremely lipid-soluble and it is widely distributed through the entire body immediately after administration. It easily crosses both the blood–brain barrier and also the placenta, and it is excreted into breast milk.
Con el fin de protegerlos de una intoxicación, siempre use tapaderas de seguridad e inmediatamente coloque los medicamentos en un lugar seguro, uno que se encuentre arriba y lejos de su vista y alcance.
Es posible que su médico necesite cambiar las dosis de sus medicamentos y que lo mantenga bajo una cuidadosa supervisión. Si United states el diazepam con cualquiera de estos medicamentos y desarrolla cualquiera de los siguientes síntomas, llame a su médico o busque atención médica de emergencia inmediatamente: mareos inusuales, aturdimiento, somnolencia extrema, respiración lenta o dificultosa o falta de capacidad de respuesta. Asegúrese de que su cuidador o sus familiares sepan qué síntomas pueden ser graves para que puedan llamar al médico o a un servicio de urgencias si usted no puede buscar tratamiento por sí mismo.
地西泮在口服後，迅速被身體吸收，藥效很快開始，以靜脈注射，藥效更快。地西泮經肝臟代謝，其代謝物經腎臟排泄，只有極少量的地西泮沒有被代謝便排泄。
Getting VALIUM with specific other medicines can cause Unwanted side effects or influence how perfectly VALIUM or one other medicines perform. Never start out or halt other medicines with out talking to your healthcare service provider.
are breastfeeding or decide to breastfeed. VALIUM passes into your breast milk and could hurt your toddler. Talk with your healthcare company about The simplest way to feed your newborn if you are taking VALIUM. Do not breastfeed whilst taking VALIUM.
Reserve concomitant prescribing of these medication in people for whom other treatment method solutions are insufficient. Limit dosages and durations on the minimum amount expected. Monitor closely for signs of respiratory melancholy and sedation.
diazepam will enhance the stage or result of lemborexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Lessen nightly dose of lemborexant suggested if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.
phenobarbital will lessen the level or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 valium sverige metabolism. Use Caution/Observe.
topiramate will minimize the extent or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
lemborexant, diazepam. Either will increase consequences of the other by sedation. Modify Therapy/Check Carefully. Dosage adjustment may be essential if lemborexant is coadministered with other CNS depressants mainly because of doubtless additive outcomes.
diazepam improves toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Check Carefully. Experiments have proven that The mix of benzodiazepines and buprenorphine altered the same old ceiling effect on buprenorphine-induced respiratory despair, creating the respiratory effects of buprenorphine surface just like People of entire opioid agonists.
Indicated for acute treatment method of intermittent, stereotypic episodes of Recurrent seizure exercise (ie, seizure clusters, acute repetitive seizures) distinctive from the patient’s usual seizure sample Utilised adjunctively in convulsive Issues, even though it has not proved helpful as the only real therapy
hydrocortisone will minimize the extent or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.